Table 3.

Associations of plasma MR-proADM levels with pulse pressure, LVMi, and UACR in separate multivariable models.

	Pulse pressure		Log LVMi		Log (UACR+1)
	β±SE	P value	β±SE	P value	β±SE	P value
Model 1	9.96±1.63	<0.0001	0.18±0.02	<0.0001	0.88±0.15	<0.0001
Model 2	4.27±1.58	<0.007	0.16±0.02	<0.0001	0.95±0.16	<0.0001
Model 3 (fully adjusted)
Age, year	5.85±0.58	<0.0001	0.05±0.01	<.0001	−0.09±0.05	0.10
Male sex	−4.95±1.14	<0.0001	0.04±0.02	0.016	0.29±0.10	0.003
BMI, Kg/m2	-	-	0.01±0.001	<.0001	-	-
History of MI and/or stroke	−3.91±1.57	0.013	0.06±0.02	0.014	0.38±0.14	0.009
Diabetes	4.67±1.14	<0.0001	0.03±0.02	0.04	0.75±0.10	<.0001
Total cholesterol, mg/dL	0.99±0.54	0.069	-	-	0.10±0.05	0.03
HDL cholesterol, mg/dL	1.35±0.55	0.014	-	-	-	-
SBP, mm Hg	-	-	0.05±0.01	<.0001	0.38±0.04	<.0001
DBP, mm Hg	-	-	-	-	-	-
Heart rate, bpm	−0.19±0.046	<0.0001	-	-	0.02± 0.004	0.0004
Log eGFR	-	-	-	-	−0.50±0.18	0.005
Beta-blocker use	-	-	0.06±0.02	0.001	0.19±0.10	0.074
Calcium channel blocker use	-	-	0.03±0.01	0.026	0.27±0.09	0.002
Diuretics use	−5.34±0.94	<0.0001	-	-	-	-
Log MR-proADM	5.08±1.59	0.0014	0.05±0.02	0.029	0.46±0.15	0.002

R² of models for pulse pressure, LVMi, and UACR model are 0.21, 0.21, and 0.24 respectively.

^*BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LVMi, left ventricular mass index; MI, myocardial infarction; MR-proADM, midregional pro-adrenomedullin; SBP, systolic blood pressure; UACR, urine albumin:creatinine ratio.

^‡Model 1 is unadjusted; model 2 is adjusted for age and sex; and model 3 is adjusted for age, sex, BMI, systolic BP, diastolic BP, eGFR, total cholesterol and HDL cholesterol, smoking history, diabetes, previous history of myocardial infarction or stroke) and the use of medications (BP-lowering and statin).