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. 2010 Mar;26(3):279–291. doi: 10.1089/aid.2009.0186

Table 1.

Inhibition of HIV-1 by β-Chemokines in the PBMC Assay

 
IC80(ng/ml) in PBMCsa
Recombinant protein Bal R5 SF162 R5 WITO R5 CH040 R5 CH058 R5 CH077 R5 WEAU R5X4
MIP-1α 400 >1250 120 126 >1250 >1250 >1250
MIP-1α/LD78β 13 43 10 7 18 109 >1250
MIP-1β >1250 >1250 1160 615 >1250 >1250 >1250
RANTES 66 171 36 37 75 >1250 >1250
IFN-γ >5000 ND ND ND ND ND >5000
MDC >1250 ND >1250 ND ND ND >1250
a

Chemokines and IFN-γ were assayed in PBMCs against PBMC-grown NL-LucR.T2A-Env.ecto reporter HIV-1 expressing the indicated envs. Values are the concentration at which RLU were reduced 80% compared to virus control wells after subtraction of background RLU in cell control wells. ND, inhibition experiments were not done with these viruses.

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