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Clinical Trials in aMCI
| Agent | N | Duration | Endpoint | Outcome |
|---|---|---|---|---|
| Donepezil | 269 | 24 weeks | Symptoms | Negative |
| Donepezil/Vitamin E | 769 | 3 years | AD | Partially positive |
| Rofecoxib | 1200 | 2–3 years | AD | Negative |
| Galantamine | 995 | 2 years | CDR 1 | Negative |
| 1062 | 2 years | CDR 1 | Negative | |
| Rivastigmine | 1018 | 3–4 years | AD | Negative |
AD, Alzheimer’s disease; CDR, clinical dementia rating.
