. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Mar 3;20(9):2987–2990. doi: 10.1016/j.bmcl.2010.02.102

Table 2.

Hydrolysis of Class 1 and 2 Compounds in Human Plasma.^a

Class 1 (Ester-Carbonate Series)		Class 2 (Ester Series)

Compound	t_1/2 (min)^b	Compound	t_1/2 (min)^b
1	204	12	38
3	135	13	63
4	253	14	< 5
5	468	18	111
7	357

Hydrolysis measured in 80 % human plasma in PBS at 37 °C.

Half-lives determined by plotting the semi-log of prodrug disappearance.