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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Int J Cancer. 2010 Mar 1;126(5):1067–1078. doi: 10.1002/ijc.24690

Figure 2.

Figure 2

TIMP-2 binding with MT1-MMP activates ERK1/2. MT1-MMP-siRNA and siRNAscr cells were incubated for 15 min in DMEM. Where indicated, TIMP-2 (100 ng/ml) alone and in combination with GM6001 (10 µM) was added. Cell lysates were analyzed by immunoblotting for pERK1/2, total ERK1/2, pSrc and total Src.