Echocardiography data from animals at baseline (18 months of age), 22 months, and in final heart failure (HF). LVIDd, left ventricular internal diameter in diastole; LVIDs, left ventricular internal diameter in systole; LVPWTd, left ventricular posterior wall thickness in diastole. Data are means ± SE.* P < 0.10 for Lard and HLSO vs. CON; ** P < 0.05 for Lard and HLSO vs. CON; † P < 0.05 vs. Baseline within CON group; ‡ P<0.05 vs. Baseline within Lard and HLSO groups.