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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Alcohol Clin Exp Res. 2007 Apr;31(4):582–595. doi: 10.1111/j.1530-0277.2007.00342.x

Fig. 10.

Fig. 10

Acute actions of baclofen against stress-elicited social interaction (SI) deficits during abstinence from ethanol diet (ED) but no effects of prophylactic baclofen in animals not exposed to ED. Groups of rats were exposed to control diet (CD) and given either vehicle (CD-Veh) or baclofen (Bac-CD) twice or were similarly exposed to CD and baclofen, followed by one 5-day cycle of 4.5% ED (Bac-ED). Two additional groups were exposed to ED for 3 cycles, behaviorally tested to confirm the sensitization of anxiety (ED-Pre Veh stress and ED-Pre Bac stress) during withdrawal, and then retested immediately after administration of a single restraint stress (45 min) 3 days into abstinence. Baclofen had no effect on rats given only CD, tended to increase anxiety in animals subsequently exposed to 1 ED cycle (Bac-ED), and completely reversed stress-elicited anxiety in the multiply withdrawn abstinent rats (ED-Post Bac stress). Bars represent the means ± SEM. Groups with different letters are significantly different from each other (Tukey’s protected t-tests). *Significantly different from the stressed Veh-treated group (ED-Post Veh stress).