Fig. 2.

Prophylactic actions of acamprosate but not ifenprodil on the reduced social interaction (SI) time induced by repeated chronic exposures to 7% ethanol diet (ED). Rats were exposed to control diet (CD) throughout or 3 cycles of 5 days’ exposure to 7% ED. Rats exposed to ED were treated with vehicle (ED-Veh), 300 mg/kg acamprosate (ED-Acamp), or 10 mg/kg ifenprodil (ED-Ifen) 4 h into the first and second withdrawals. Social interaction behavior and line crossings were recorded 5 h after the last withdrawal. Data represent the means ± SEM. Groups with different letters are significantly different from each other (Tukey’s protected t-tests).