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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Alcohol Clin Exp Res. 2007 Apr;31(4):582–595. doi: 10.1111/j.1530-0277.2007.00342.x

Fig. 5.

Fig. 5

Prophylactic effects of flumazenil but not naloxone on reduced social interaction (SI) behavior in rats repeatedly withdrawn from 4.5% ethanol diet (ED). Rats were exposed to control diet (CD) throughout or 3 cycles of 5 days’ exposure to 4.5% ED. Rats exposed to ED were injected with vehicle (ED-Veh), 20 mg/kg naloxone (ED-NLX), or 5 mg/kg flumazenil (ED-Flu) 4 h into the first and second withdrawals. Social interaction behavior and line crossings were recorded 5 h after the third ethanol exposure was stopped. Bars represent the means ± SEM. Groups with different letters are significantly different from each other (Tukey’s protected t-tests).