Table 1.
Body Weights and Ethanol Intakes in the Drug Treatment Groups Do Not Differa
| Treatment group | Ethanol intake (g/kg/d) | Body weight (g) |
|---|---|---|
| Experiment 1 | ||
| CD-Veh | NA | 271 ± 6 |
| ED-Veh | 13.0 ± 0.5 | 261 ± 8 |
| ED-Diaz | 13.2 ± 0.3 | 275 ± 10 |
| ED-Flu | 12.4 ± 0.7 | 241 ± 14 |
| ED-Bac1.25 | 13.3 ± 0.3 | 283 ± 9 |
| ED-Bac2.5 | 12.7 ± 0.3 | 274 ± 10 |
| F(4, 25) = 0.99; NS | F(5, 34) = 2.24; NS | |
| Experiment 2 | ||
| CD-Veh | NA | 302 ± 2 |
| ED-Veh | 11.2 ± 0.3 | 312 ± 10 |
| ED-Acamprosate | 11.1 ± 0.3 | 300 ± 6 |
| ED-Ifenprodil | 11.6 ± 0.4 | 308 ± 6 |
| F(2, 20) = 0.45; NS | F(3, 35) = 0.80; NS | |
| Experiment 3 | ||
| CD-Veh | NA | 302 ± 3 |
| ED-Veh | 11.3 ± 0.3 | 301 ± 6 |
| ED-Lamot | 11.3 ± 0.3 | 309 ± 5 |
| ED-Dizocilpine (MK-801) | 10.9 ± 0.3 | 294 ± 3 |
| ED-CGS | 10.8 ± 0.3 | 296 ± 2 |
| F(3, 30) = 0.95; NS | F(4, 37) = 2.03; NS | |
| Experiment 4 | ||
| CD-Veh | NA | 288 ± 5 |
| ED-Veh | 10.6 ± 0.5 | 299 ± 7 |
| ED-MPEP | 10.6 ± 0.3 | 298 ± 8 |
| t(14) = 0.02; NS | F[2, 21] = 0.83; NS | |
| Experiment 5 | ||
| CD-Veh | NA | 331 ± 2 |
| ED-Veh | 9.2 ± 0.1 | 328 ± 7 |
| ED-NLX | 8.9 ± 0.2 | 336 ± 5 |
| ED-Flu | 9.2 ± 0.9 | 333 ± 5 |
| F(2, 20) = 0.94; NS | F(3, 28) = 0.47; NS | |
| Experiment 6 | ||
| CD-Veh | NA | 325 ± 3 |
| ED-Vehicle | 8.6 ± 0.3 | 351 ± 8 |
| ED-BacA | 9.0 ± 0.3 | 350 ± 9 |
| ED-BacP | 9.2 ± 0.2 | 332 ± 12 |
| F(2, 20) = 0.64; NS | F(3, 27) 2.24; NS | |
| Experiment 7 | ||
| CD-Veh | NA | 312 ± 4.4 |
| ED-Veh | 8.8 ± 0.2 | 307 ± 2.8 |
| ED-Bac1.25 | 9.4 ± 0.3 | 313 ± 3.4 |
| ED-Bac5 | 8.6 ± 0.5 | 302 ± 6.5 |
| ED-NLX | 8.7 ± 0.4 | 309 ± 6.7 |
| F(3, 28) = 1.15; NS | F(4, 35) = 0.78; NS | |
| Experiment 8 | ||
| CD-Veh | NA | 301 ± 4.6 |
| ED-Veh | 10.1 ± 0.5 | 286 ± 5.3 |
| ED-Flum | 9.9 ± 0.4 | 289 ± 5.0 |
| ED-NLX | 9.7 ± 0.4 | 289 ± 4.5 |
| ED-Bac | 9.7 ± 0.3 | 290 ± 4.2 |
| F(3, 28) = 0.15; NS | F(4, 35) = 1.56; NS | |
| Experiment 9 | ||
| CD-Veh | NA | 305 ± 2.5 |
| ED-Veh | 9.2 ± 0.2 | 305 ± 6.1 |
| Stress-ED-Veh | 9.7 ± 0.2 | 307 ± 3.4 |
| Stress-ED-Bac1.25 | 8.8 ± 0.2 | 290 ± 6.7 |
| Stress-ED-Bac5 | 9.0 ± 0.3 | 307 ± 6.7 |
| F(3, 25) = 2.64; NS | F(4, 35) = 1.99; NS | |
| Experiment 10 | ||
| CD-Veh | NA | 309 ± 4.7 |
| Bac-CD | NA | 305 ± 3.4 |
| Bac-ED | 10.5 ± 0.3 | 307 ± 7.6 |
| ED-Pre Veh stressb | 9.6 ± 0.3 | 316 ± 6.1 |
| ED-Pre Bac stressb | 9.8 ± 0.2 | 314 ± 3.1 |
| F(2, 21) = 3.34, p<0.06 | F(4, 35) = 1.14; NS |
Rats consumed ethanol or control diets for three 5-d cycles with prophylactic drug treatments during periods of withdrawal at the end of the first 2 of 3 cycles or acute treatments at the conclusion of a continuous 23-d ethanol exposure.
Note, after their first social interaction test, animals in these 2 groups were abstinent for 3 d, and then treated with Baclofen for the first time 30 min before administering 45 min of restraint stress and testing with a new partner for social interaction (SI) 30 min later. Social interaction and locomotor data from both the behavioral tests are shown in Fig. 10.
NA, not applicable; NS, not significant; Bac, baclofen; BacA, acute baclofen; BacP, prophylactic baclofen; CGS, CGS19755; Diaz, diazepam; NLX, naloxone; Veh, vehicle; CD, control diet; ED, ethanol diet; Flum, flumazenil; Lamot, lamotrigine; MK, MK-801.