Figure 1.

Effects of Tyk2 and LPS on overall gene expression. Effects of (A) Tyk2 genotype (Wt minus Tyk2-/-), (B) LPS treatment (6 hours of LPS minus control), and (C) genotype by treatment interaction (difference in LPS induction between Wt and Tyk2-/-) on expression levels of all genes, plotted as normed effect coefficients (NCs) (y-axis) against relative ranks (absolute rank divided by the number of genes; x-axis). Thick solid lines represent NCs; thin solid lines the values expected under the assumption of the null hypothesis and normality.