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. 2010 Mar 25;11:199. doi: 10.1186/1471-2164-11-199

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Copyright ©2010 Vogl et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Tyk2 and LPS on genes with IRF/ISRE TFBS. Effects of (A) Tyk2 genotype (Wt minus Tyk2-/-), (B) LPS treatment (6 hours of LPS minus control), and (C) genotype by treatment interaction (difference in LPS induction between Wt and Tyk2-/-) on expression levels of genes containing the IRF/ISRE TFBS, plotted as NCs (y-axis) against relative ranks (absolute rank divided by the number of genes; x-axis). Thick solid lines represent NCs; thin solid lines the values of all genes (see Figure 1) in order to highlight the effects on genes with IRF/ISRE TFBS relative to all genes analyzed.