Table 1. Active compounds against intracellular L.major.
L. major | L. donovani | Cytotoxicity CC50 THP-1 | |||
Compound code | EC50 promastigote | EC50 amastigote | EC50 promastigote | EC50 amastigote | |
CH872 | 0.1 µM | 0.3 µM | 0.05 µM | 0.06 µM | >10.0 µM |
CA272 | 2.7 µM | 0.8 µM | 2.7 µM | 19.0 µM | >10.0 µM |
NJ231 | 0.8 µM | 11.0 µM | 0.6 µM | >20.0 µM | >10.0 µM |
CG170 | 1.0 µM | 8.0 µM | 0.1 µM | 14.0 µM | >10.0 µM |
TE122 | 7.8 µM | 12.0 µM | 3.0 µM | ≫20.0 µM | >10.0 µM |