Table 4. Effect of depletion of target molecules on parasite growth, viability, mitochondrial potential.

Gene	Relative live cell numbera	% dead cells	Relative mito ψb
TOPIBS	n.d.	35	1.10
	0.16	28	1.34
TOPIBL	n.d.	72	1.33
	0.21	28	0.93
TOPIImt	0.08	44	0.44
	0.51	19	0.33
PFTB	0.36	14	0.72
	0.3	17	0.68
PEX19	n.d.	64	0.47
	0.26	61	0.52
KREPA3	0.05	37	0.19
	0.15	19	0.41
NOPP44/46	0.04	26	0.34
	0.12	17	0.53

^aDefined as the cumulative reduction in live cell number relative to uninduced controls at day of assay. TOP1BS, TOP1BL, and PEX19 knockdowns were assayed on day 2 post induction of RNAi, while PFTB and NOPP44/46 knockdowns were assayed on day 3 and TOPIImt on day 6. KREPA3 was assayed five days after removal of Tet.

^bas compared to control cells in the same experiment.