Table 1.
Baseline characteristics of enrolled patients.
| Characteristic | Treatment arm | ||
|---|---|---|---|
| Number of patients randomized | CQ (n = 268) | DP (n = 268) | P |
| Gender: Male/Female (ratio) | 126/142 (0.89) | 132/136 (0.97) | 0.60 |
| Age, median years (range) | 11 (0.25 -71) | 12 (1 - 70) | 0.38 |
| Age Groups: | 0.18 | ||
| <5 years | 43 (16.0) | 30 (11.2) | |
| 5 -14 years | 130 (48.5) | 128 (47.8) | |
| >14 years | 95 (35.5) | 110 (41.0) | |
| Location: | 0.61 | ||
| Jalalabad | 154 (57.5) | 160 (59.7) | |
| Taloqan | 58 (21.6) | 61 (22.8) | |
| Maimana | 56 (20.9) | 47 (17.5) | |
| Weight, median kg (range) | 30 (5-93) | 33 (7-89) | 0.69 |
| Geometric mean parasitaemia/μL (95% CI) | 3339 (3000-3716) | 3236 (2940 -3560) | 0.67 |
| Number with gametocytes | 218 (81.3) | 203 (75.2) | 0.12 |
| Haemoglobin concentration, mean g/dl (SD) | 10.9 (1.46) | 10.9 (1.42) | 0.99 |
| Anaemia (haemoglobin concentration < 10 g/dl) | 49 (18.4) | 44 (16.5) | 0.35 |
| Median white blood cells ×109/ml, median (range) | 6.0 (3.6-54) | 6.6 (3.0-12.4) | 0.02 |
| Body temperature °C, mean (95% CI) | 37.3 (37.2-37.4) | 37.3 (37.2-37.4) | 0.77 |
| Median systolic blood pressure, mmHg (range) | 100 (80-160) | 100 (80-170) | 0.43 |
| Median diastolic blood pressure, mmHg (range) | 70 (50-100) | 70 (50-100) | 0.38 |
| Median pulse rate, beat/min (range) | 88 (60-140) | 88 (60-140) | 0.53 |
| Jaundice | 30 (11.3) | 32 (12.1) | 0.79 |
| History of convulsions in last 24 hours | 1 (0.37) | 1 (0.37) | |
Data for chloroquine (CQ) and dihydroartemisinin-piperaquine (DP) are number (%) unless otherwise indicated.