Figure 2.

Associations between single-nucleotide polymorphism rs6626269 or rs4778137 and overall survival. Per-allele hazard ratios (HRs) and 95% confidence intervals (CIs) are presented. A) Nonstratified analyses for rs6626269 and rs4778137. B) Analyses for rs4778137 stratified by estrogen receptor (ER) status (ER positive [ER+] and ER negative [ER−]). Data are shown for analyses with the hypothesis-generating set (Studies of Epidemiology and Risk factors in Cancer Heredity [SEARCH]), individual studies in the validation dataset, the entire validation set, and a combined dataset (overall) containing data from the hypothesis-generating set and the validation set. Supplementary Table 1 (available online) presents descriptions of all studies. Squares = study-specific hazard ratios; area of the each square = inverse of the variance of the estimate; horizontal lines = 95% CIs; diamonds = summary hazard ratio estimates encompassing 95% CIs; dotted vertical line = combined summary hazard ratio. Hazard ratio statistical significance assessed by a trend test with 1 df. Study heterogeneity was assessed by use of the I² statistic. All statistical tests were two-sided. BBCC = Bavarian Breast Cancer Cases and Controls; CGPS = Copenhagen Breast Cancer Study and Copenhagen General Population Study; CNIO-BCS = Spanish National Cancer Centre Breast Cancer Study; GESBC = Genetic Epidemiology Study of Breast Cancer by Age 50; HEBCS = Helsinki Breast Cancer Study; KARBAC = Karolinska Breast Cancer Study; KBCP = Kuopio Breast Cancer Project; kConFab/AOCS = The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer/Australian Ovarian Cancer Study; MCBCS = Mayo Clinic Breast Cancer Study; MCCS = Melbourne Collaborative Cohort Study; ORIGO = Leiden University Medical Centre Breast Cancer Study; PBCS = Polish Breast Cancer Study; SASBAC = Singapore and Swedish Breast Cancer Study; SBCS = Sheffield Breast Cancer Study; UCIBCS = University of California Irvine Breast Cancer Study.