Figure 3.

Cumulative overall survival among patients with estrogen receptor (ER)–negative breast cancer by genotype of the single-nucleotide polymorphism rs4778137. A Kaplan–Meier analysis was used. Total patients at risk in the analysis and number of patients at risk and overall survival rates with 95% confidence intervals (95% CI) for years 5, 10, and 15 after breast cancer diagnosis are presented. A) Cumulative survival for patients in the hypothesis-generating dataset from the Studies of Epidemiology and Risk factors in Cancer Heredity (SEARCH) study. B) Cumulative survival for patients in the validation set. C) Cumulative survival for patients in the combined hypothesis-generating and validation datasets. D) Predicted cumulative survival adjusted for study site for patients in the combined hypothesis-generating and validation datasets, adjusted to the baseline hazard function of the SEARCH study. All four analyses were stratified by rs4778137 genotype (C = common; G = rare). ** = patient numbers were too few to estimate a survival rate at this time point.