Table 3.

Associations between single-nucleotide polymorphisms, rs6626269 and rs4778137, and overall survival, stratified by breast cancer prognostic factors: Studies of Epidemiology and Risk factors in Cancer Heredity (SEARCH) study^*

Prognostic factor	rs6626269			rs4778137
	HR (95% CI)	P for interaction†	P for heterogeneity‡	HR (95% CI)	P for interaction†	P for heterogeneity‡
Stage
I	1.33 (1.04 to 1.69)	.79	.95	0.90 (0.71 to 1.15)	.19	.17
II	1.36 (1.16 to 1.60)			0.68 (0.57 to 0.80)
III or IV	1.42 (0.98 to 2.06)			0.73 (0.51 to 1.05)
Grade
Well differentiated	1.52 (1.00 to 2.31)	.35	.57	0.81 (0.53 to 1.24)	.67	.91
Moderately differentiated	1.44 (1.16 to 1.79)			0.74 (0.59 to 0.93)
Poorly differentiated	1.25 (1.01 to 1.55)			0.73 (0.59 to 0.90)
ER status
Positive	1.44 (1.18 to 1.75)	.83	.53	0.91 (0.75 to 1.10)	.0024	.0056
Negative	1.29 (1.00 to 1.68)			0.56 (0.41 to 0.75)

^*Hazard ratios (HRs) were calculated within strata of each prognostic factor and were not adjusted for other prognostic factors. CI = confidence interval; ER = estrogen receptor.

^†Statistical significance based on a two-sided likelihood ratio test with 1 df.

^‡Statistical significance based on a two-sided test for heterogeneity with 1 df.