Table 4.

Associations between single-nucleotide polymorphisms (SNPs), rs6626269 or rs4778137, and overall survival: Studies of Epidemiology and Risk factors in Cancer Heredity (SEARCH), validation, and combined datasets^*

SNP	Gene (chromosomal band and position)†	Alleles‡	MAF§	SEARCH dataset			Validation dataset			Combined dataset
				No. of patients	Per-allele HR (95% CI)	P for trend	No. of patients	Per-allele HR‖ (95% CI)	P for trend	No. of patients	Per-allele HR‖ (95% CI)	P for trend
rs6626269	FMR1 (Xq27.3 and  chrX:146673425)	A, G	0.21	3752	1.35 (1.19 to 1.52)	2.2 × 10−6	10 960	1.02 (0.94 to 1.11)	.64	14 712	1.11 (1.04 to 1.19)	.0025
rs4778137	OCA2 (15q13.1 and  chr15:28327835)
Total		C, G	0.30	3755	0.76 (0.67 to 0.86)	1.9 × 10−5	13 712	0.98 (0.92 to 1.05)	.54	17 467	0.93 (0.87 to 0.98)	.011
ER positive				1978	0.91 (0.75 to 1.10)	.32	8865	1.01 (0.92 to 1.10)	.92	10 843	0.99 (0.91 to 1.10)	.75
ER negative				498	0.56 (0.41 to 0.75)	9.2 × 10−5	2656	0.88 (0.78 to 0.99)	.030	3154	0.82 (0.73 to 0.92)	5.0 × 10−4

^*Statistical significance based on a 1 df trend test. All statistical tests were two-sided. CI = confidence interval; ER = estrogen receptor; HR = hazard ratio; MAF = minor allele frequency.

^†Gene name, chromosomal band, and chromosomal position based on dbSNP building 130 (ftp.ncbi.nih.gov/snp).

^‡Common allele and rare allele.

^§The MAF was based on SEARCH population data.

^║Fixed-effects meta-analysis of study-specific hazard ratios.