Table 5.

Associations between single-nucleotide polymorphisms (SNPs), rs6626269 or rs4778137, and overall survival in adjusted analyses: Studies of Epidemiology and Risk factors in Cancer Heredity (SEARCH), validation, and combined datasets^*

SNP	Gene (chromosomal band and position)†	Alleles‡	MAF§	SEARCH dataset			Validation dataset			Combined dataset
				No. of patients	Per-allele HR (95% CI)	P for trend	No. of patients	Per-allele HR‖ (95% CI)	P for trend	No. of patients	Per-allele HR‖ (95% CI)	P for trend
rs6626269	FMR1 (Xq27.3 and  chrX:146673425)	A, G	0.21	2201	1.49 (1.25 to 1.77)	5.9 × 10−6	6113	0.99 (0.88 to 1.11)	.83	8314	1.11 (1.01 to 1.22)	.03
rs4778137	OCA2 (15q13.1 and  chr15:28327835)
Total		C, G	0.30	2205	0.72 (0.61 to 0.86)	2.8 × 10−4	7855	0.95 (0.87 to 1.05)	.31	10 060	0.9 (0.83 to 0.97)	.009
ER-positive				1762	0.83 (0.67 to 1.03)	.10	6246	0.97 (0.87 to 1.08)	.52	8008	0.94 (0.85 to 1.03)	.2
ER-negative				443	0.54 (0.40 to 0.74)	1.4 × 10−4	1609	0.9 (0.76 to 1.07)	.25	2052	0.79 (0.68 to 0.92)	.002

^*Statistical significance based on 1 df trend test. All statistical tests were two-sided. CI = confidence interval; ER = estrogen receptor; HR = hazard ratio; MAF = minor allele frequency.

^†Gene name, chromosomal band, and chromosomal position based on dbSNP building 130 (ftp.ncbi.nih.gov/snp).

^‡Common allele and rare allele.

^§This value is based on SEARCH population data.

^║Cox proportional hazards models adjusted for age at diagnosis and stratified by study stage, grade, and ER status.