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. 2010 May 4;7(5):e1000272. doi: 10.1371/journal.pmed.1000272

Table 1. Breakdown of the 11 major epidemiological research domains according to categories 1–4.

Category Research Domain Detailed Research Objectives
1. Investigation and surveillance Description of the outbreak Time, place, and persons
Search for causative agent Identification
Characteristics
Transmission Determine the modes and routes of transmission
Estimate the transmission probability and variability
Predict future trends of the present outbreak
Risk factors Determine the risk factors and disease determinants
2. Case management Clinical presentations Describe the clinical features, pathophysiological evolution, immune response, and associated clinical complications
Diagnostic assays Development and evaluation of their sensitivity and specificity
Treatments and medical interventions Assess efficacy and adverse events of treatment and medical interventions
Prognosis Describe patient outcomes
Identify prognostic factors
Medical decision making Promote planning and policy-making by health services
3. Prevention and control Prevention and control measures Describe the use of specific control measures in the population
Estimate and evaluate effectiveness of the control measures
Develop methods and/or tools for real-time monitoring during the outbreak
4. Psychobehavior Psychobehavioral investigations Assess the level of personal knowledge and perception of risk
Assess the personal attitudes and preventive measures taken regarding the outbreak threat
Evaluate SARS-related individual psychological and social impacts