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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Mol Cell Neurosci. 2010 Feb 1;43(4):414–421. doi: 10.1016/j.mcn.2010.01.008

Figure 4.

Figure 4

Taurine preservation of cone photoreceptors in VGB-treated neonatal rats. (A–K) Retinal sections from control animals (A, G, J), VGB-treated rats (B, H, K) and VGB-treated rats administered with taurine (C, I) stained with peanut lectin (PNA, in A–C) or immuno-labelled with an antibody directed against the cone arrestin (D–K): sections were examined by light (A–F) or confocal microscopy (G–K). Note the decrease in PNA-positive inner/outer segments of photoreceptors (B) or cone-arrestin immunpositive cells (F, H) in VGB-treated rats in comparison with control animals (A, D, G) and neonatal VGB-treated rats that had taurine injections (C, F, I). Enlarged views of cone-arrestin immuno-labelled photoreceptors showing the morphological changes in a VGB-treated rat (K) in comparison with a normal cone photoreceptor (J). (L) Quantification of cone inner/outer segment densities in control rats (n=10), in VGB-treated animals with (VGB + taurine, n=10) or without (VGB, n=10) taurine administration. The scale bar represents 50 μm (A–F), 10μm (G–I) and 1μm (J–K). (ONL=outer nuclear layer, INL=inner nuclear layer, OPL=outer plexiform layer, s.e.m., *p<0.05; **p<0.001).