Table 1.
Amino acid levels in the plasma of neonatal rats untreated (control), treated with vigabatrin (VGB) or treated with both vigabatrin and taurine (VGB + taurine). The differences were statistically significant for taurine level between VGB-treated animals and either the control group or VGB-treated animals administered with taurine.
| Amino acids | Control | VGB | VGB+taurine |
|---|---|---|---|
| Taurine | 244.9±54.3 | 178.7±23.6 | 244.3±42.5* |
| Threonine | 153.2±32.7 | 158.3±30.3 | 169.3±35.1 |
| Serine | 198.7±40.6 | 206.4±40.2 | 224.3±32 |
| Glutamic acid | 110.5±34.2 | 104.8±37.7 | 113.8±25.5 |
| Valine | 189.1±27.4 | 184.5±33 | 176.8±28.1 |
| Citrulline | 135.5±18.3 | 126.7±16 | 142.8±18 |
| Alanine | 521.2±99.6 | 516.3±115.1 | 531±77.3 |
| Glycine | 225.4±46.3 | 222.6±36.6 | 254.2±52 |
| Proline | 318.4±62.2 | 310±50.3 | 313.6±62.5 |
| Glutamine | 694.2±71 | 621±88.5 | 614.1±76.4 |
| Methionine | 54.9±10.5 | 57.3±8 | 58.2±9.8 |
| Isoleucine | 93.6±12.1 | 92.7±15.3 | 88.8±13.6 |
| Leucine | 169.1±20.5 | 193.3±36.7 | 191.2±46.2 |
| Tyrosine | 64.3±12.2 | 68.5±16.4 | 67.6±18.1 |
| Phenylalanine | 62.4±6.4 | 62.5±8.3 | 64.7±7.3 |
| Arginine | 135.7±19.5 | 125.1±30.9 | 128.4±22.5 |
| Histidine | 46.3±5.5 | 51.8±10.5 | 48.7±4.4 |
| Lysine | 265±47.7 | 223.8±89.1 | 241.6±24.5 |
| Ornithine | 85.8±13.9 | 84±16.7 | 90.1±14.6 |
Measurements are provided in μM (n=10, s.e.m.)
*
p<0.05.