Fig. 6.

The protein expression of arginase I was lower in TNF^−/− mice, higher in TNF^++/++ mice, and in between of TNF^−/− and TNF^++/++ mice in TNF^−/++ mice than that in WT mice (Fig. 6a, b). Following I/R, arginase mRNA expression (Fig. 6c) was elevated in the WT, substantially elevated in the TNF^−/++ and TNF^++/++ mice, and not affected in the TNF^−/− mice. Antibody neutralization of TNF decreased arginase expression in the WT, TNF^−/++ and TNF^++/++ mice, but did not affect arginase expression in the TNF^−/− mice. * P < 0.05 versus sham; ^# P < 0.05 versus I/R