Figure 2.

Statistical methods indicated that argyrophilic grains (AGs) are not associated with CILA severity in our research cohorts. To evaluate these data, we studied separately the 75 cases with AGs in our sample. A chart (A) shows how the actual pre‐mortem mini‐mental status examination (MMSE) scores for patients correlated to the amount of AG pathology. The AG score is proportional to the severity of AGs in entorhinal cortex, subiculum and cornu ammonis hippocampal fields. Note that there is no decrease in MMSE scores as AG pathology worsens. A photomicrograph of Gallyas‐stained cornu ammonis (B) from the individual in our autopsy cohort with the most severe AG pathology, a 91‐year old woman who died without any cognitive impairment (MMSE score = 30 less than 8 months prior to death). Scale bar = 50 µm.