Table 7.

A subset of cases evaluated for TDP‐43 immunohistochemistry (IHC): demographics and mini‐mental status examination (MMSE) data (actual and predicted results). Demographics and MMSE data from the 49 cases stained for TDP‐43 IHC. Cases with abTPD‐43 had aberrant IHC in dentate granule cells (n = 18) and/or neurofibrillary tangle (NFT)‐like and neuropil thread‐like TDP‐43 immunoreactive profiles in the hippocampal formation (n = 21). Note that the actual MMSE score proximal to death was lower for the cases with abTDP‐43(+), and was even lower than the MMSE scores predicted using the regression algorithm that includes the known clinical and pathological risk factor for cognitive impairment linked to aging.

	n	Formal education, years	Braak stage	Age at death, years	Final MMSE score	Final predicted MMSE score
Cases with abTDP‐43 IHC	25	15.6	4.7	85.0	9.1	16.0
Cases without abTDP‐43 IHC	24	15.9	4.2	85.0	17.0	20.7