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. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Exp Neurol. 2009 Aug 7;223(2):385–393. doi: 10.1016/j.expneurol.2009.07.029

Table 1.

Electrophysiological properties.

Passive Membrane Properties		WT	TG	NFT−	NFT+

Membrane time constant (ms)		32.5 ± 4.1	35.2 ± 3.4	36.5 ± 4.6	33.4 ± 5.3
Input resistance (MΩ)		197 ± 23	228 ± 23	257 ± 35	189 ± 28
Membrane resting potential (mV)		−74.9 ± 1.1	−67.0 ± 1.1^***	−67.6 ± 1.6	−66.18 ± 1.6

Single AP Properties
Rheobase (mA)		92 ± 14	73 ± 7	66 ± 8	81 ± 14
Threshold (mV)		−35.8 ± 0.5	−34.8 ± 1.7	−34.4 ± 2.7	−35.5 ± 1.8
Amplitude (pA)		86.3 ± 0.9	84.3 ± 1.3	82.8 ± 1.4	86.3 ± 2.5
Duration (ms)		1.42 ± 0.05	1.25 ± 0.05^*	1.30 ± 0.06	1.19 ± 0.07
Sag Amplitude (mV)		2.23 ± 0.46	5.94 ± 0.62^***	5.76 ± 0.90	5.54 ± 0.93

^*

p<0.02

^***

p<0.0001