. Author manuscript; available in PMC: 2010 May 5.

Published in final edited form as: Am J Psychiatry. 2010 Feb 16;167(5):589–597. doi: 10.1176/appi.ajp.2009.09020280

TABLE 3.

Multivariate Cox Regression Models Examining Associations Between Neuropsychiatric Symptoms and Mortality in Older Adults

	Symptoms						Symptoms
Model^a	Total Neuropsychiatric Symptoms			Depressed Mood			Anhedonia			Anergia			Apathy
	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p
1 (N=498)	1.3	1.1–1.5	<0.001	2.0	1.4–2.9	<0.001	1.6	1.0–2.4	0.020	1.8	1.3–2.5	<0.001	1.1	0.8–1.7	0.530
2 (N=498)	1.3	1.1–1.4	<0.001	1.9	1.3–2.8	<0.001	1.6	1.0–2.4	0.030	1.6	1.2–2.3	0.005	1.2	0.8–1.8	0.390
3 (N=461)	1.3	1.1–1.5	<0.001	2.2	1.5–3.2	<0.001	1.7	1.0–2.7	0.039	1.6	1.1–2.4	0.012	1.4	0.9–2.1	0.130

Model 1 adjusted for cognitive status, age, gender, education, and race. Model 2 adjusted for cognitive status, age, gender, education, race, and the presence of lacunes. Model 3 adjusted for cognitive status, age, gender, education, race, the presence of lacunes, and all vascular conditions simultaneously; the lower sample size in this model is due to missing data on the vascular condition variables.