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. 2009 Dec 16;95(5):730–737. doi: 10.3324/haematol.2009.017392

Figure 4.

Figure 4.

Additive contributions of ICAM-4 and CD36 to increased adhesion of SAD RBC to endothelium. A and B: RBC were incubated in the presence 10 μg/mL monoclonal antibody anti-mouse CD36 or control mouse IgG, for 30 min. Anti-CD36 antibody significantly reduced the adhesion of SAD RBC (P<0.05) (A), but not that of wild-type (WT) RBC (B). C and D: RBC were treated with anti-CD36 mono-clonal antibody or control IgG, and bEnd.3 cell monolayers with 250 μM T-8-I or A-8-C peptide, for 30 min. The double treatment resulted in a highly significant fall of SAD RBC adhesion (C) and a moderate fall of WT RBC adhesion (D) (P<0.001 by ANOVA). Columns represent mean results from four different mice, and bars represent SEM.