Table 2.

GM Regions that Show Significant Differences between FXS and Control Groups.

	ROI Name	Region	Brodmann Area	Talairach Coordinates			T value	P value (FWE)	Cluster Size
				X	Y	Z
Gray Matter: FXS > TD, DD
	A	Right Caudate Body, Head		14	2	19	10.28	<0.001	7120
				14	19	−2	7.07	<0.001
	B	Left Caudate Body, Head		−17	4	20	9.11	<0.001	6699
				−12	21	−1	7.29	<0.001
	C	Left Precentral, Inferior Frontal Gyri	6	−44	−1	28	7.11	<0.001	591
	D	Right Fusiform Gyrus	18, 19	37	−76	−12	6.77	<0.001	1857
				41	−86	−12	6.22	0.001
				31	−91	−15	6.2	0.001
	E	Bilateral Thalamus (Dorsal Medial, Ventral Anterior Nuclei), Hypothalamus		6	−10	13	6.71	<0.001	1506
				−7	−11	13	6.61	<0.001
				−8	−14	5	6.39	<0.001
	F	Left Middle, Superior Occipital Gyri	19	−43	−86	19	6.59	<0.001	714
	G	Right Anterior Cerebellum		26	−45	−24	6.37	<0.001	322
	H	Left Cingulate Gyrus	23	−5	−26	32	5.57	0.01	235
Gray Matter: TD, DD > FXS
	a	Right Insula	13	30	12	11	9.21	<0.001	4951
				40	−4	19	8.22	<0.001
	b	Left Insula	13	−39	−3	19	9.17	<0.001	3801
				−30	14	13	8.05	<0.001
	j	Right Hippocampal Gyrus		33	−39	8	6.87	<0.001	2514
				30	−57	17	5.55	0.004
	c	Right Postcentral Gyrus, Inferior Parietal Lobule (IPL)	40,1,3	57	−27	20	6.74	<0.001	5899
				58	−16	43	6.62	<0.001
				62	−7	16	6.41	<0.001
	d	Right Postcentral Gyrus, IPL	40	49	−30	48	6.68	<0.001	556
				62	−28	41	5.54	0.011
	e	Right Medial Frontal Gyrus	10	13	52	−6	6.48	<0.001	484
	f	Right Inferior Frontal Gyrus	44,45	53	17	18	6.44	<0.001	1162
				59	9	19	5.95	0.002
	g	Left Middle Frontal Gyrus	11	−22	41	−13	6.34	<0.001	431
	h	Left Medial Frontal Gyrus		−10	53	5	6.19	0.001	1372
				−12	44	13	5.95	0.002
				−9	43	0	5.68	0.006
	k	Left Hippocampal Gyrus		−33	−37	6	6.14	<0.001	468
	i	Left IPL, Postcentral Gyrus	40	−62	−34	38	6.09	0.001	395
	j	Right Medial Frontal Gyrus	11	6	44	−14	5.96	0.002	408
				15	39	−15	5.8	0.004
	k	Left Precentral Gyrus	6,4	−62	−4	27	5.87	0.003	1083
				−61	−10	38	5.76	0.005
				−65	−19	42	5.15	0.045
	l	Left Superior Temporal, Precentral Gyri	22,4	−62	−8	3	5.59	0.009	232
				−54	−8	5	5.39	0.019