Table 2.
Estimates of incidence and number of new cases of RSV-associated ALRI and severe ALRI in children younger than 5 years from studies§ with active and passive case ascertainment, by GBD region
|
RSV-associated ALRI |
RSV-associated severe ALRI |
||||
|---|---|---|---|---|---|
| Incidence in children aged <1 year (per 1000 per year) | Number of new cases in children aged <5 years in 2005 (×103) | Incidence in children aged <1 year (per 1000 per year) | Number of new cases in children aged <5 years in 2005 (×103) | ||
| Developing countries | |||||
| Active | |||||
| Number of studies | 6 (1) | 6 (4) | 4 (0) | 4 (3) | |
| Median estimate | 78·5 (33–116) | 66 (27–94) | 15·5 (13·5–38·6) | 7 (4–14) | |
| Meta-estimate | 74·2 (50·2–109·7) | 59·1 (40–87·5) | 22·3 (9·4–52·9) | 8·3 (4·4–15·6) | |
| Passive | |||||
| Number of studies | 1 | 1 | 10 (4) | 10 (3) | |
| Median estimate | NA | NA | 15·4 (11–19) | 4·7 (3–9) | |
| Meta-estimate | NA | NA | 16·4 (13·2–20·5) | 5 (3·7–6·7) | |
| Active and passive | |||||
| Number of studies | 7 (1) | 7 (5) | 14 (4) | 14 (6) | |
| Median estimate | 53 (33–116) | 48 (27–94) | 15·4 (13–19) | 4·7 (4–10) | |
| Meta-estimate | 68·4 (46·5–100·5) | 54·6 (37·1–80·4) | 17·9 (14·5–22·2) | 5·6 (4·3–7·4) | |
| Industrialised countries | |||||
| Active | |||||
| Number of studies | 0 | 0 | 0 | 0 | |
| Passive | |||||
| Number of studies | 1 | 1 | 15 (4) | 15 (10) | |
| Median estimate | NA | NA | 18 (12–28) | 4·7 (3–9) | |
| Meta-estimate | NA | NA | 19 (14·6–24·7) | 5·5 (4·2–7·2) | |
| Global | |||||
| Developing* | 59·1 (40–87·5) | 32512 | 5·6 (4·3–7·4) | 3080·7 | |
| Industrialised† | 24 (19·8–30) | 1301·7 | 5·5 (4·2–7·2) | 298·3 | |
| Total‡ | 48·5 (31·4–74·9) | 33813·7 | 5·6 (4·5–7) | 3379 | |
Data are number of studies (imputed number), median estimate (IQR), or meta-estimate (95% CI). References 35 and 36, Singleton et al, and the Epi study were excluded because these studies were of Indigenous populations in industrialised countries; references 19 and 38 excluded because of insufficient data. RSV=respiratory syncytial virus. ALRI=acute lower respiratory infection. GBD=global burden of disease.
Incidence estimates for RSV-associated ALRI based on the meta-estimate for active studies only and for severe ALRI on the meta-estimate for both active and passive studies.
Incidence for RSV-associated ALRI based on the estimate from one passive study only and incidence for severe ALRI on the meta-estimate from passive studies.
Total incidence for RSV-associated ALRI was calculated on the basis of the meta-estimate from active studies in developing countries plus the estimate from passive study in industrialised countries; total incidence for RSV-associated severe ALRI was on the basis of the meta-estimate from active and passive studies in developing countries plus the meta-estimate from passive studies in industrialised countries.