Fig. 1.
Effects of myricetin on UVB-induced blood vessel formation in SKH-1 hairless mice. Myricetin inhibits UVB-induced neovascularization in SKH-1 hairless mouse skin. (a) Vehicle-treated controls, (b) UVB-irradiated (0.18 J/cm2) mice and UVB plus (c) mice treated with 8 nmol myricetin or (d) mice treated with 20 nmol myricetin. Fifteen mice were treated topically with myricetin (8 or 20 nmol in 200 μl of acetone/mouse) or vehicle as described in Materials and Methods and then irradiated with UVB light 3× a week for 27 weeks. Photographs of blood vessels in the mice were taken after euthanization at the end of the experiment using a Samsung digital camera.