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. 2009 Dec 3;31(5):880–885. doi: 10.1093/carcin/bgp285

Fig. 5.

Fig. 5.

PEITC or DBM altered proteins involved in cell cycle regulation, apoptosis and Nrf2-regulated detoxification enzymes. (A) DBM greatly induced Nrf2 and its downstream detoxifying enzymes. DBM but not PEITC before AOM initiation induced Nrf2 protein in the normal mucosa. The Nrf2-regulated downstream detoxifying enzymes GSTM1, HO-1 and NQO-1 were also greatly induced by DBM treatment. (B) PEITC greatly induced p21 and cleaved caspase-3 and-7. PEITC administration showed a substantial p21 induction in the polyps, before or after initiation. Induction of another cell cycle arrest marker p27 was less substantial. Cleaved caspase-3 and-7 (C-casp3 and 7) was substantially induced by PEITC administrated both before and after AOM initiation. Induction of pro-apoptotic protein Bim was also higher by PEITC than by DBM.