Table II.
Identity and functions of those miRNA that were affected by either BUD or PEITC in the lung and liver of Sham- and/or ECS-exposed mice
| miRNA | Regulated functions |
| let-7a/c | Cell proliferation, Ras activation, angiogenesis |
| miR-15a | Cell shape and motility, cell proliferation, stress response, protein secretion, inflammation |
| miR-21 | Protein repair, stress response, cell proliferation |
| miR-26a | Transforming growth factor expression |
| miR-27a | Cell proliferation, stress response, protein repair |
| miR-29b | Collagen production, inflammation |
| miR-31 | Protein synthesis and secretion, stress response |
| miR-34c | P53 effector |
| miR-100 | Apoptosis |
| miR-106b | Cell adhesion, TNF activation, stress response |
| miR-125a | Erbb2 activation |
| miR-125b | Stress response |
| miR-133 | Angiogenesis, linkage between muscle fiber and basement membrane |
| miR-135b | Regulation of Ras-related activities involved in cell membrane homeostasis, cell focal adhesion and gene transcription |
| miR-142 | Protein repair, DNA repair, prostaglandin-mediated platelet aggregation |
| miR-153 | Protein repair, protein synthesis, signal transduction |
| miR-181 | Stress response |
| miR-200b | Intracellular trafficking, protein repair |
| miR-292 | Hepatocyte growth factor-induced cell proliferation, angiogenesis |
| miR-297a/b | Protein repair, cell cycle progression |
| miR-299 | NF-κB activation, stress response, peroxisome activation |
| miR-300 | Protein repair, intracellular trafficking, cell proliferation |
| miR-320 | Cell adhesion, protein repair, intracellular trafficking, cell proliferation |
| miR-322 | Protein repair, cell proliferation |
| miR-323 | Peroxisome activation, protein repair |
| miR-331 | Stress response |
| miR-338 | Protein repair, stress response |
| miR-376b | Cell cycle progression, signal transduction, apoptosis, intracellular vesicle trafficking |
| miR-382 | Endocytosis, angiogenesis, protein repair |
| miR-452 | Stress response, cell cycle arrest in response to DNA damage |
| miR-463 | Cell proliferation, protein repair, stress response |
| miR-466a/b/f | Apoptosis, protein repair, cell proliferation |
| miR-467a | Cell proliferation, protein synthesis |
| miR-467d | NA |
| miR-467e | Cell proliferation, stress response |
| miR-470 | Ras activation, intracellular vesicle trafficking, xenobiotic metabolism |
| miR-483 | NA |
| miR-539 | Protein repair, intracellular trafficking |
| miR-551 | DNA repair, inflammation, cell proliferation |
| miR-666 | Protein repair, stress response |
| miR-687 | Tumor suppression by phosphatidylinositol catabolism, cell proliferation |
| miR-690 | Cell proliferation, cell adhesion |
| miR-697 | Protein repair, intracellular trafficking, cell adhesion |
| miR-706 | Intracellular trafficking, cell motility, TNF activation |
| miR-708 | Stress response, TNF and NF-κB activation |
| miR-709 | Stress response, inflammation, lysosome activation |
| miR-710 | Cell proliferation, collagen production, Ras activation |
| miR-719 | Inflammation |
| miR-742 | Protein repair, stress response |
| miR-763 | Cell membrane integrity, peroxisome biogenesis, stress response |
| miR-874 | Protein repair, intracellular vesicle trafficking, cell proliferation, P53-dependent apoptosis, inflammation, stress response |
| miR-879 | Peroxisome activation |
| miR-883a | Tumor suppressing activity through phosphatidylinositol catabolism, protein synthesis, intracellular vesicle trafficking, protein repair, cell proliferation |
NA, no target genes having a context score >0.30 is available in the Targetscan database; NF-κB, nuclear factor-kappaB; TNF, tumor necrosis factor.