Table III.
ORs and 95% CIs for biliary tract cancers and stones in relation to ESR1 1801132 (P325P) by gender, BMI and stone status
| Genotype | Controls |
Gallbladder cancera |
Bile duct cancerb |
Ampulla of Vater cancerb |
Biliary stonesc |
||||
| n | n | OR (95% CI)d | n | OR (95% CI)d | n | OR (95% CI)d | n | OR (95% CI)d | |
| Gender | |||||||||
| Males | |||||||||
| CC | 92 | 18 | 1.0 | 10 | 1.00 | 6 | 1.0 | 89 | 1.0 |
| CG | 142 | 37 | 1.3 (0.7–2.5) | 44 | 2.8 (1.4–5.9) | 11 | 1.1 (0.4–3.2) | 163 | 1.1 (0.7–1.6) |
| GG | 66 | 10 | 0.7 (0.3–1.7) | 20 | 2.8 (1.2–6.3) | 6 | 1.4 (0.4–4.6) | 73 | 1.1 (0.7–1.8) |
| P-trend | 0.60 | 0.02 | 0.58 | 0.65 | |||||
| CG/GG | 208 | 47 | 1.1 (0.6–2.1) | 64 | 2.8 (1.4–5.7) | 17 | 1.2 (0.5–3.2) | 236 | 1.1 (0.8–1.6) |
| Females | |||||||||
| CC | 127 | 47 | 1.0 | 13 | 1.0 | 1 | 1.0 | 160 | 1.0 |
| CG | 235 | 79 | 0.9 (0.6–1.4) | 25 | 1.0 (0.5–2.1) | 12 | — | 272 | 0.9 (0.7–1.3) |
| GG | 115 | 43 | 1.0 (0.6–1.6) | 12 | 1.0 (0.4–2.3) | 10 | — | 128 | 0.9 (0.6–1.3) |
| P-trend | 0.92 | 0.98 | — | 0.62 | |||||
| CG/GG | 350 | 122 | 0.9 (0.6–1.4) | 37 | 1.0 (0.5–2.0) | 22 | — | 400 | 0.9 (0.7–1.3) |
| P-heterogeneitye | 0.6 | 0.01 | — | 0.4 | |||||
| BMI | |||||||||
| BMI < 23 kg/m2 | |||||||||
| CC | 100 | 30 | 1.0 | 9 | 1.00 | 5 | 1.0 | 83 | 1.0 |
| CG | 188 | 44 | 0.7 (0.4–1.3) | 43 | 2.6 (1.2–5.7) | 7 | 0.7 (0.2–2.2) | 160 | 1.2 (0.8–1.8) |
| GG | 95 | 16 | 0.5 (0.3–1.01) | 11 | 1.4 (0.5–3.4) | 9 | 1.7 (0.5–5.5) | 95 | 1.6 (1.0–2.4) |
| P-trend | 0.05 | 0.57 | 0.26 | 0.06 | |||||
| CG/GG | 283 | 60 | 0.6 (0.4–1.1) | 54 | 2.2 (1.0–4.7) | 16 | 1.0 (0.4–2.9) | 255 | 1.3 (0.9–1.9) |
| BMI ≥ 23 kg/m2 | |||||||||
| CC | 119 | 35 | 1.0 | 14 | 1.0 | 2 | 1.0 | 166 | 1.0 |
| CG | 188 | 72 | 1.3 (0.8–2.1) | 26 | 1.2 (0.6–2.3) | 16 | — | 275 | 0.9 (0.7–1.3) |
| GG | 86 | 36 | 1.3 (0.8–2.3) | 21 | 2.1 (0.9–4.4) | 7 | — | 105 | 0.8 (0.5–1.2) |
| P-trend | 0.28 | 0.05 | — | 0.26 | |||||
| CG/GG | 274 | 108 | 1.3 (0.9–2.1) | 47 | 1.4 (0.8–2.8) | 23 | — | 380 | 0.9 (0.6–1.2) |
| P-heterogeneitye | 0.06 | 0.45 | — | 0.39 | |||||
| Stone status | |||||||||
| No stones | |||||||||
| CC | 158 | 14 | 1.0 | 4 | 1.00 | 3 | 1.0 | ||
| CG | 293 | 16 | 0.7 (0.3–1.5) | 26 | 3.5 (1.2–10.4) | 11 | — | ||
| GG | 134 | 6 | 0.6 (0.2–1.5) | 10 | 3.1 (1.0–10.4) | 4 | — | ||
| P-trend | 0.23 | 0.08 | — | ||||||
| CG/GG | 427 | 22 | 0.7 (0.3–1.4) | 36 | 3.4 (1.2–9.9) | 15 | — | ||
| Stones | |||||||||
| CC | 61 | 51 | 1.0 | 19 | 1.0 | 4 | 1.0 | ||
| CG | 84 | 100 | 1.7 (1.0–2.9) | 43 | 1.8 (0.9–3.5) | 12 | — | ||
| GG | 47 | 47 | 1.0 (0.6–1.8) | 22 | 1.4 (0.6–3.0) | 12 | — | ||
| P-trend | 0.92 | 0.35 | — | ||||||
| CG/GG | 131 | 147 | 1.4 (0.9–2.2) | 65 | 1.7 (0.9–3.1) | 24 | — | ||
| P-heterogeneitye | 0.05 | 0.22 | — | ||||||
Bold values are statistically significant at P < 0.05.
a
Gallbladder cancer cases compared with controls without cholecystectomy (n = 737).
b
Bile duct and ampulla of Vater cancer cases compared with all controls (n = 786).
c
Biliary stone cases compared with controls without biliary stones (n = 592).
d
ORs (95% CI) were adjusted for age and sex.
e
P-heterogeneity by Breslow–Day test.