Fig. (4).

Inhibition of OATP-mediated FMTX uptake by known inhibitors/substrates. Uptake of 5 µM FMTX was measured for 30 min at room temperature on 96-well plates with OATP-expressing and wild-type CHO cells in the absence or presence of the indicated compounds. Values obtained with wild-type CHO cells were subtracted from values obtained with OATP-expressing cells and are given as percent of control. Means ± SE of two combined independent experiments each performed with quadruplicate determinations are shown. ^* p < 0.05; E3S: estrone-3-sulfate; E17βG: estradiol-17β-glucuronide.