Table 1.
Statistics of Prestwick Library Screening
| OATP1B1 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Plate number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Mean (neg control) | 5,170 | 5,906 | 5,428 | 7,400 | 6,166 | 4,984 | 4,866 | 6,113 | 5,670 | 6,713 | 6,390 | 6,054 | 6,042 | 9,159 |
| STDEV (neg control) | 390 | 1,107 | 807 | 924 | 579 | 645 | 451 | 721 | 634 | 1,150 | 425 | 605 | 444 | 921 |
| Mean (pos control) | 9,411 | 10,044 | 9,499 | 14,100 | 10,904 | 9,080 | 8,950 | 11,267 | 10,641 | 11,879 | 12,990 | 12,183 | 14,967 | 16,572 |
| STDEV (pos control) | 871 | 715 | 753 | 1,520 | 1,267 | 803 | 537 | 1,042 | 935 | 1,663 | 954 | 1,226 | 1,249 | 1,760 |
| Sample mean | 9,654 | 10,381 | 9,101 | 13,350 | 9,857 | 8,448 | 8,967 | 11,136 | 10,397 | 11,423 | 12,343 | 11,735 | 12,785 | 16,997 |
| Z' factor | 0.11 | -0.32 | -0.15 | -0.09 | -0.17 | -0.06 | 0.27 | -0.03 | 0.05 | -0.63 | 0.37 | 0.10 | 0.43 | -0.08 |
| OATP1B3 | ||||||||||||||
| Plate number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Mean (neg control) | 7,161 | 8,034 | 7,766 | 10,591 | 7,901 | 7,506 | 7,734 | 9,639 | 8,273 | 8,231 | 8,418 | 9,093 | 9,047 | 9,856 |
| STDEV (neg control) | 760 | 1,315 | 1,037 | 1,814 | 523 | 834 | 1,194 | 1,495 | 761 | 332 | 370 | 472 | 570 | 1,026 |
| Mean (pos control) | 26,768 | 31,694 | 27,097 | 31,987 | 28,351 | 25,272 | 30,369 | 26,319 | 26,882 | 30,781 | 31,653 | 34,132 | 34,603 | 32,986 |
| STDEV (pos control) | 1,704 | 2,889 | 1,778 | 1,212 | 1,789 | 2,271 | 2,257 | 1,792 | 1,171 | 4,063 | 1,281 | 3,003 | 3,917 | 3,014 |
| Sample mean | 26,308 | 26,850 | 23,819 | 33,715 | 26,838 | 25,368 | 25,738 | 29,565 | 26,661 | 29,799 | 29,365 | 33,188 | 31,714 | 36,503 |
| Z' factor | 0.62 | 0.47 | 0.56 | 0.58 | 0.66 | 0.48 | 0.54 | 0.41 | 0.69 | 0.42 | 0.79 | 0.58 | 0.47 | 0.48 |