Table 2.
Physiological Parameters
| |
|
Time course during 5-h infusion |
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|---|---|---|---|---|---|---|---|---|---|
| |
|
Pre-insult (min) |
MCAO (min) |
Reperfusion (min) |
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| Parameters | Baseline | 30 | 60 | 10 | 60 | 120 | 10 | 60 | 120 |
| Sham-operated | |||||||||
| MABP (mm Hg) | 95 ± 4 | 96 ± 5 | 92 ± 5 | 93 ± 4 | 94 ± 7 | 94 ± 8 | 96 ± 7 | 96 ± 6 | 97 ± 2 |
| Rectal temperature (°C) | 36.2 ± 0.5 | 36.4 ± 0.2 | 36.7 ± 0.3 | 36.3 ± 0.4 | 36.5 ± 0.3 | 36.2 ± 0.5 | 36.7 ± 0.4 | 36.4 ± 0.4 | 36.4 ± 0.2 |
| pH | 7.42 ± 0.04 | 7.40 ± 0.04 | 7.40 ± 0.03 | 7.40 ± 0.03 | 7.40 ± 0.03 | 7.41 ± 0.02 | |||
| Paco2 (mm Hg) | 39 ± 6 | 39 ± 3 | 41 ± 6 | 42 ± 5 | 40 ± 9 | 39 ± 3 | |||
| Pao2 (mm Hg) | 133 ± 9 | 145 ± 20 | 134 ± 25 | 128 ± 7 | 135 ± 24 | 132 ± 12 | |||
| Injured, vehicle | |||||||||
| MAP (mm Hg) | 94 ± 8 | 97 ± 9 | 94 ± 10 | 108 ± 8 | 98 ± 5 | 99 ± 5 | 95 ± 9 | 99 ± 6 | 97 ± 6 |
| Rectal temperature (°C) | 36.5 ± 0.3 | 36.7 ± 0.3 | 36.6 ± 0.5 | 36.6 ± 0.4 | 36.3 ± 0.3 | 36.2 ± 0.3 | 36.3 ± 0.4 | 36.4 ± 0.4 | 36.3 ± 0.5 |
| pH | 7.42 ± 0.04 | 7.44 ± 0.02 | 7.40 ± 0.03 | 7.36 ± 0.03 | 7.39 ± 0.04 | 7.40 ± 0.03 | |||
| Paco2 (mm Hg) | 41 ± 5 | 37 ± 2 | 40 ± 2 | 41 ± 4 | 39 ± 4 | 38 ± 4 | |||
| Pao2 (mm Hg) | 142 ± 25 | 140 ± 16 | 130 ± 14 | 134 ± 7 | 129 ± 14 | 133 ± 12 | |||
| Injured, 50 μg/kg PMA | |||||||||
| MAP (mm Hg) | 94 ± 5 | 94 ± 2 | 91 ± 3 | 106 ± 7 | 97 ± 7 | 99 ± 10 | 93 ± 7 | 98 ± 7 | 100 ± 8 |
| Rectal temperature (°C) | 36.3 ± 0.4 | 36.8 ± 0.4 | 30.6 ± 0.1 | 36.3 ± 0.4 | 36.4 ± 0.2 | 36.7 ± 0.2 | 36.8 ± 0.3 | 36.6 ± 0.3 | 36.5 ± 0.3 |
| pH | 7.40 ± 0.03 | 7.4 ± 0.03 | 7.36 ± 0.03 | 7.36 ± 0.03 | 7.37 ± 0.03 | 7.37 ± 0.03 | |||
| Paco2 (mm Hg) | 40 ± 4 | 39 ± 6 | 44 ± 4 | 42 ± 2 | 42 ± 4 | 42 ± 3 | |||
| Pao2 (mm Hg) | 127 ± 21 | 140 ± 18 | 127 ± 11 | 126 ± 13 | 135 ± 26 | 121 ± 9 | |||
| Injured, 200 μg/kg PMA | |||||||||
| MAP (mm Hg) | 93 ± 5 | 97 ± 5 | 92 ± 7 | 110 ± 8 | 99 ± 9 | 99 ± 10 | 95 ± 11 | 99 ± 8 | 98 ± 8 |
| Rectal temperature (°C) | 36.4 ± 0.4 | 36.8 ± 0.3 | 36.4 ± 0.3 | 36.3 ± 0.4 | 36.6 ± 0.2 | 36.7 ± 0.2 | 36.2 ± 0.3 | 36.8 ± 0.2 | 36.5 ± 0.4 |
| pH | 7.41 ± 0.06 | 7.41 ± 0.06 | 7.39 ± 0.06 | 7.38 ± 0.03 | 7.42 ± 0.09 | 7.39 ± 0.03 | |||
| Paco2 (mm Hg) | 40 ± 9 | 42 ± 7 | 33 ± 6 | 41 ± 5 | 40 ± 5 | 41 ± 6 | |||
| Pao2 (mm Hg) | 143 ± 19 | 145 ± 19 | 139 ± 19 | 133 ± 20 | 128 ± 20 | 129 ± 17 | |||
Data are expressed as mean ± SD; n = 6 rats/group; MCAO, middle cerebral artery occlusion; MAP, mean arterial pressure; PMA, phorbol 12-myristate 13-acetate; Paco2, partial arterial carbon dioxide pressure; Pao2, partial arterial oxygen pressure; SD, standard deviation.