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. 2009 Oct;26(10):1783–1793. doi: 10.1089/neu.2007.0502

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Copyright 2009, Mary Ann Liebert, Inc.

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FIG. 3. — Behavioral tests conducted at 7 and 14 DPI to analyze the effect of buprenorphine on functional locomotor recovery. BBB scores were used to evaluate the locomotor recovery of the animals, and there was no significant difference between the injured animals treated and untreated with buprenorphine at 7 or 14 DPI, the same was observed for the sham animals (A). Grid-walking analysis demonstrated that injured animals made more errors than sham animals. However there was no significant difference in the number of errors performed by the rats when the two groups (injured with buprenorphine versus saline treated, and sham with buprenorphine versus saline treated) were compared at 7 and 14 DPI (B). Beam crossing was also performed on the same animals and the same results were observed; there was no significant difference observed when both groups were compared at 7 and 14 DPI (C). None of the comparisons were significant (p > 0.05), using two-way ANOVA followed by Bonferroni multiple-comparison test, with the exception of sham animals compared to injured rats. The values presented are the mean ± SEM.