Figure 1.

Concentrations of prostate tumor-derived cytokines circulating in plasma and platelets. Plasma (A, B) and releasates from platelets (C, D) activated with 500 µM PAR-4 and 100 nM PMA were isolated from mice injected subcutaneously with LNCaP-C4-2 (C42, black columns) or PBS (Control, white columns). A species-specific array for human proteins was used to determine the concentrations of tumor-derived cytokines; represented as mean values ± SEM. No tumor-derived proteins were found in the plasma or platelets of control mice, demonstrating the specificity of the array. *P < .05, **P < .01, and ***P < .005 versus control by one-way ANOVA.