Figure 4.

Predominantly host contributions to cytokine concentrations in plasma and platelet releasate. (A–D) Plasma and releasates from platelets activatedwith 500 µM PAR-4 and 100 nMPMA (Platelets) were isolated frommice injected subcutaneouslywith human LNCaP-C4-2 cells. Species-specific protein arrays were used to determine the concentrations ofmurine (Host Derived, white columns) and human (Tumor Derived, black columns) cytokines and growth factors. Concentrations are represented as mean values ± SEM. Percentages represent the contribution of host (in black) or tumor (in white) to the total protein in plasma or platelets.