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. Author manuscript; available in PMC: 2010 May 5.
Published in final edited form as: Biomaterials. 2008 Dec 19;30(8):1657–1664. doi: 10.1016/j.biomaterials.2008.12.002

Figure 5.

Figure 5

Predictions of release from (A) bulk eroding and (B) surface eroding poly(ortho ester) matrices. Predictions have been made for the experimental data for dye release (astricks), while accounting for the hydrolysis of the anhydride excipient, with the complete model (solid line, (A) SSE = 0.0237 and (B) SSE = 1.1539) and the simplified version which assumes bulk erosion (dashed line, (A) SSE = 1.0077 and (B) SSE = 0.0061). For calculations in both A and B, the following parameters were used: Mwo = 28.2 kDa, Mwr = 10.2 kDa, Rp = 5 mm, and L = 1.4 mm. Based on their differing anhydride contents, values of DA were unique to A and B, with DA = 1.44 × 10-12 m2/s in A and DA = 9.75 × 10-12 m2/s in B.