Table 1.

Comparison of the Structure and Function of the Serine Protease Inhibitors SLPI and Elafin, Two Closely Related Members of the WAP Family of Proteins

Structure/Function	SLPI	Elafin
Size	11.7 kDa (117 amino acids)	6 kDa (57 amino acids)
WAP domains	2	1
pI	9.5	9.7
Anti-protease activities	Neutrophil elastase, cathepsin G, chymase, trypsin, chymotrypsin	Neutrophil elastase, proteinase 3
Anti-bacterial	E. coli, P. aeruginosa, S. aureus	P. aeruginosa, S. aureus
Anti-inflammatory	Inhibits NF-κB activation and cytokine production	Inhibits NF-κB and AP-1 activation and cytokine production