Skip to main content
. Author manuscript; available in PMC: 2010 May 5.
Published in final edited form as: J Med Chem. 2002 Jul 18;45(15):3210–3221. doi: 10.1021/jm010461a

Table 4.

Linear Cross-Correlation Matrix of the GCODs Found in the Best 4D-QSAR Models

Part A: Potentiation of GABAA Responses
(−1,−1,−2,hb d) (−2,3,3, any) (0,−1,−2,p−) (0,−3,1,np) (0,0,3, any) (1,4,−4, any)
(−1,−1,−2,hb d) 1.00
(−2,3,3, any) −0.15 1.00
(0,−1,−2,p−) −0.23 −0.07 1.00
(0,−3,1,np) −0.17 −0.13 0.81 1.00
(0,0,3, any) 0.41 −0.44 0.05 0.13 1.00
(1,4,−4, any) 0.31 −0.08 −0.11 −0.16 0.23 1.00
Part B: Direct Activation
(−1,−1,−1,hbd) (1,−2,2, any) (0,2,−3, any) (1,2,−4, any) (1,3,−1, any) (2,0,5, any)
(−1, −1, −1, hbd) 1.00
(1,−2,2, any) −0.21 1.00
(0,2,−3, any) 0.20 −0.17 1.00
(1,2,−4, any) 0.33 −0.18 0.26 1.00
(1,3,−1, any) 0.14 −0.19 −0.09 0.06 1.00
(2,0,5, any) −0.16 −0.13 −0.10 −0.11 −0.35 1.00
Part C: Tadpole LORR
(−1,−1,−2,hbd) (−4,2,−2, any) (0,−3,1, any) (1,−4,3,np) (1,−2,2,np) (1,5,1, any)
(−1,−1,−2,hbd) 1.00
(−4,2,−2, any) 0.13 1.00
(0,−3,1, any) 0.04 −0.02 1.00
(1,−4,3,np) 0.60 0.56 −0.10 1.00
(1,−2,2,np) −0.27 −0.12 0.09 −0.20 1.00
(1,5,1, any) −0.13 −0.07 −0.08 −0.13 −0.14 1.00