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Linear Cross-Correlation Matrixes of the −log(EC50) Values of the Three Activity Screens
| Part A for 27 Analogues | |||
|---|---|---|---|
| potentiation | direct activation | tadpole LORR | |
| Potentiation | 1.00 | ||
| Direct activation | 0.97 | 1.00 | |
| Tadpole LORR | 0.96 | 0.96 | 1.00 |
| Part B for Active Analogues Only | |||
| potentiation | direct activation | tadpole LORR | |
| potentiation | 1.00 | ||
| Direct activation | 0.88 | 1.00 | |
| Tadpole LORR | 0.68 | 0.78 | 1.00 |
