Table 4.
Univariable and multivariable log-linear regression analysis on organ transplantation
| Covariate | Unadjusteda Slope Estimate (95% Confidence Interval) | p Value | Adjustedb Slope Estimate (95% Confidence Interval) | p Value |
|---|---|---|---|---|
| Donor age (per 5 yrs) | −0.12 (−0.19, −0.05) | .001 | v0.10 (−0.18, −0.01) | .028 |
| Female gender | −0.10 (−0.41, 0.61) | .70 | ||
| History of hypertension | −0.59 (−1.13, −0.06) | .02 | ||
| Acute Physiology and Chronic Health Evaluation II | −0.02 (−0.06, 0.01) | .17 | ||
| Vasopressor (norepinephrine units) | 0.20 (−0.43, 0.83) | .54 | ||
| Interleukin-6c | −0.28 (−0.47, −0.10) | .003 | −0.20 (−0.39, −0.01) | .035 |
| Tumor necrosis factorc | −0.37 (−0.74, −0.01) | .042 | ||
| Interleukin-10c | −0.05 (−0.26, 0.16) | .62 | ||
| Preload responsiveness | −0.62 (−1.18, −0.07) | .028 |
In unadjusted analysis, younger donor age was significantly associated with higher number of organs transplanted, such that for each 5-yr increase in donor age from mean age of 53 yrs there was an approximately 11% decrease in the number of organs transplanted. Higher mean IL-6 was also significantly associated with lower number of organs transplanted, such that mean number of organs transplanted decreased by about 25% for each 1-log pg/mL increase in mean IL-6 concentration from 5 log pg/mL to 6 log pg/mL. Similarly, increased mean TNF concentration was significantly associated with lower number of organs transplanted. On average, preload responsive donors donated fewer organs compared with unresponsive donors;
in multivariable analysis, younger donor age was significantly associated with higher number of organs transplanted such that for each 5-yr increase in donor age from the mean age of 53 yrs, there was a 10% decrease in the number of organs transplanted. Mean IL-6 concentration was also significantly associated with the number of organs transplanted. In particular, mean organ transplanted decreased by about 18% for each 1-log pg/mL increase in mean IL-6 concentration. Although mean TNF concentrations and preload responsiveness were significantly associated with lower number of organs transplanted, when adjusted for age, mean log IL-6 concentrations, history of hypertension, and vasopressors, the associations were not statistically significant. Variables that were not statistically significant (p > .05) predictors are not shown;
all cytokine concentrations are expressed in means of natural logarithm/pg/mL.