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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Nat Immunol. 2010 Jan 19;11(2):114–120. doi: 10.1038/ni.1837

Figure 4.

Figure 4

Functional effects of different amounts of Bcl-6 and Blimp-1 expression. The amount of Bcl-6 and Blimp-1 expression is balanced differently in different lymphocytes at distinct differentiation stages. Lymphocytes with higher expression of Bcl-6 exhibit greater proliferative capacity but less secretory capacity. Lymphocytes with higher expression of Blimp-1 exhibit lower proliferative capacity and greater secretory capacity. Although exhausted CD8+ T cells have large amounts of Blimp-1 and lower proliferative capacity, they do not have more secreted effectors. TCM, central memory T cell; TEM, effector memory T cell.