TABLE 2.

Clinical differences between the serological classifications of autoimmune hepatitis

	Autoimmune hepatitis
	Type 1	Type 2
Relative prevalence	>80%	20% in Europe, 4% in United States
Autoantibodies commonly associated	Antinuclear, antismooth muscle	Liver kidney microsome-1
Patient demographic	Approximately 70% women	Female predominance
Age of onset	Peak incidence between 16 and 30 years of age, although 50% are older than 30 years of age	Average 10 years of age but seen in adults, specifically in Europe
Other commonly associated autoimmune diseases	Prevalence of 17% to 48%. Thyroid disease, synovitis, ulcerative colitis	Prevalence unclear. Diabetes, thyroid disease, vitiligo, pernicious anemia
Presentation	Acute onset rare	Frequently presents with cirrhosis in children and more aggressively
Response to treatment	Excellent	May be more treatment resistant
Progression of disease	25% have cirrhosis at diagnosis; 45% develop cirrhosis	Approximately 80% develop cirrhosis