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Positions of Cys residues within APE1. The human APE1 (PDB identifier, 1BIX, gray ribbon rendering) includes seven Cys residues (black sticks), whose positions relative to the active-site His 309 are shown. None of the Cys residues is appropriately positioned to form a disulfide bond, and the redox-critical Cys residue, Cys 65, is a buried residue located in the first β strand of the APE1 fold.
