FIG. 12.

Structural comparison of DNA-binding domains from transcription factors that are reported to be redox regulated by APE1/Ref-1 bound to DNA. Proteins are shown in a gray ribbon rendering, and the DNA in a spline/stick representation in black. The DNA-binding domains of the leucine zipper–motif protein AP-1 (c-Jun/c-Fos) bound to DNA (PDB identifier 1FOS) is shown in (A), the immunoglobulin-like fold of p53 (PDB identifier 1TSR) with an α helix bound in the major groove (B), and the heterodimeric two-domain immunoglobulin-like folds of p65/p50 NF-κB (PDB identifier 1VKX) in (C). A representative basic leucine-zipper/basic helix-loop-helix–containing protein (MyoD) bound to DNA (PDB identifier 1MDY) is shown in (D) to illustrate the type of interaction expected for HIF-1α bound to DNA.